Sentence examples for mutation that enhances from inspiring English sources

In the current study, we have analyzed the vaccine efficacy of an attenuated M. tuberculosis strain that combines a mutation that enhances T cell priming (ΔsecA2) with a strongly attenuating lysine auxotrophy mutation (ΔlysA).

We show that neither mutations that prevent nor a mutation that enhances Rad51 binding in vitro have a measurable effect on HR in vivo.

We show that miR-146a functions as an oncogene by activating Notch signaling, and that during melanoma progression pre-miR-146a can acquire a somatic mutation that enhances its oncogenic activity.

To explore state dependence, we generated gain-of-function mutants based on mutations previously shown to increase the open probability of Slo1 channels: R196Q is equivalent to an S4 mutation that enhances voltage activation (Diaz et al., 1998), whereas F304Y is analogous to a pore mutation that directly increases open probability (Lippiat et al., 2000).

We show that mutations that prevent Rad51 binding to the C-terminal motif in Brca2 lead to the faster disappearance of nuclear foci that mark Rad51 assemblies on damaged DNA, whereas a mutation that enhances Rad51 binding has the opposite effect.

Moreover, SPAK-knockout mice [ 36], or knockin mice expressing a form of SPAK or OSR1 that cannot be activated by WNK kinase isoforms [ 37], exhibit low blood pressure and are resistant to hypertension when crossed to animals bearing a PHAII-causing knockin mutation that enhances WNK4 expression [ 38].

We note that tco89 -71 also suppresses weakly at 33° but in this case, the original suppressor strain contained a second mutation that enhanced the suppression at 33°.

Although it is challenging, if we obtain mutations that enhances the expression of transgenes generally, we will be able to apply such mutations to increase the expression of useful genetic tools.

A mutational strategy that combines elimination of buried free cysteines and secondary mutations that enhance thermostability to achieve a substantial gain in functional half-life is described.

This variant was engineered to combine mutations that enhance MBP solubility and affinity purification, as well as provide crystal-packing interactions for increased crystallizability.

In contrast, native-like Env trimers fail to activate B cells expressing germline antibodies but elicit bNAbs by selecting for a restricted group of light chains bearing specific somatic mutations that enhance neutralizing activity.