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Now, researchers think they know why: a mutation that enabled some flu viruses to beat the vaccine.
But couldn't the viruses evolve a mutation that enabled it to invade a respiratory cell?
To illustrate the magnitude of the transformation, imagine a "mutation" that enabled humans to fly.
For the re-lysogenized derivative, we observed survival kinetics identical to that of the original Wip2 lysogen (Figure 3K); thus, there was no adaptive mutation that enabled lysogen survival.
DOI: http://dx.doi.org/10.7554/eLife.09696.014 We hypothesize that the gltA1 mutation critically affected the fitness consequence of the pivotal evolutionary step toward innovation: the citT mutation that enabled the first citrate import into cells and the weak Cit+ phenotype.
(17) We reasoned that the mutant harboring the Tn 5 in pfs must have acquired a suppressor mutation that enabled growth and affected CAI-1 production by changing the levels of metabolites related to SAM.
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A mutation that enables infection and transmission among immune persons will give the new mutant strain a selective advantage.
All vectors containing the ccdB gene were propagated in the E. coli strain DB3.1, which contains the gyrA462 mutation that enables propagation of Gateway vectors encoding the ccdB gene [35].
E. coli DB3.1 contains the gyrA462 mutation that enables propagation of Gateway vectors encoding the ccdB gene [ 21]. A. tumefaciens GV3101 pMP900 [ 43] was used to assess the functionality of plant transformation vectors.
First, there is near certainty (~100%) regarding development of the disease with a known mutation that enables prevention studies and increases the power of treating minimally or presymptomatic patients.
Thus, the conformational element caused by the G93A mutation that enables C4F6 binding does not appear to be due to a stable change in local structure around the 90 93 loop.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com