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Alpha1-antitrypsin deficiency results from point mutations that distort the structure of the protein to allow a unique protein protein interaction that we have termed loop-sheet polymerization.
Mutation scanning in particular is reliant on heteroduplex formation that distorts the shape of the melting curve as compared with a normalised curve of a wild-type reference (Reed et al, 2007).
To this end, we generated specific mutations that distorted the UCS canyon to different degrees (detailed description in the Supplemental Information).
That distorts both law and logic.
That distorts the whole political discourse.
She has a gene mutation that caused tuberous sclerosis.
"That distorts the market against bundling".
There is a rare mutation that does the same thing.
This is achieved by introducing a filter that targets highly recurrent mutations that would otherwise distort the network.
The shared SNPs presumably arose before the migration of modern humans out of Africa and are therefore depleted from recent deleterious mutations that otherwise could distort selective signals.
From the market-making perspective, all factors that distort the market process must be removed.
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