Sentence examples for mutation that displays from inspiring English sources

SRC2 was recruited to the IL6, IL8, and ICAM1 promoters, and this recruitment was completely abolished by the GR-S425G mutation that displays reduced affinity for nGREs (Fig. 7g).

The research focuses on a specific example of a mtDNA mutation that displays different phenotypic effects based on the nuclear background in which it is expressed, and offers a plausible mechanistic explanation for the variable penetrance observed in human mitochondrial diseases.

Expression of this variant in Xenopus oocytes showed alterations in activation and deactivations kinetics, but the changes were relatively mild compared with the previously reported KCNC3Phe448Leu mutation that displayed a much more significant gain-of-function in our heterologous expression system [6].

In this line and as a proof of principle we introduced a histone point mutation that displayed enhanced autophagy during aging.

This model revealed that the mutations that displayed the greatest in vivo UV sensitivity in Drosophila did not correlate with those that led to tumor formation in humans.

This and other redundant functions of LIN-35 were identified in genetic screens for mutations that display synthetic phenotypes in conjunction with loss of lin-35.

For the remaining five conserved mutations that displayed altered Kd values (Ser-177, Ser-182, His-185, Thr-186, Gln-188), there was no corresponding change in affinity for the Ala mutants, indicating that it was not the chemical characteristics of the residue that was critical at these positions.

Generally speaking, mutations that display low penetrance also tend to exert milder effects on the clinical phenotype and/or protein function, while the more highly penetrant a mutation is, the less frequent it is likely to be in the general population (Coventry et al. 2010; Marth et al. 2011; Gorlov et al. 2011; Tennessen et al. 2012; Nelson et al. 2012; Subramanian 2012; Fu et al. 2013).

A non-consequential Leu157 to Ala (L157A) mutation that displayed much reduced foci formation and TfR binding had normal TfR distribution, normal surface TfR level and normal Tf internalization.

From the calculated iP and molecular weight (Mw) for the mutated and non-mutated contigs that displayed non-synonymous mutation, the variation in iP ranged from -1.95 to 1.09, and the Mw from -97.11 kDa to 66.08 kDa.

Thus, a more comprehensive understanding of the V domain mutations that allowed display would be beneficial.