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The rs17203281 was a synonymous mutation that did not change amino acid isoleucine at codon 432.
The effect required protein expression, as cells expressing GBV-C NS5A RNA in which a frame-shift mutation that did not express NS5A did not inhibit HIV [33].
Surprisingly, each of the PA-G342 mutations resulted in an increased level of binding of PA to ANTXR1-expressing cells, except for the deletion mutation that did not affect the amount bound.
As a consequence, the spectrum of potential future adaptations will differ from those available to a population that by chance fixed an alternative mutation that did not engender a trade-off, and therefore would not select for a compensatory mutation.
However, it is impossible with this method to measure the frequency of each allele and any mutation that did not reach a frequency detectable on the chromatogram was not recorded.
Ten sub-lines harboured wild-type p53, whereas the cell line UKF-NB-3rRITA10 μ MIV harboured an A76T mutation that did not result in a loss of p53 function and remained sensitive to nutlin-3-induced anticancer effects and nutlin-3-induced p53 activation.
Similar(53)
Susie's fold was caused by a genetic mutation that does not appear in every kitten.
There is a rare mutation that does the same thing.
A neutral mutation that does not change protein structure, including synonymous coding region changes.
The rs17203281 at exon 12 is a synonymous mutation that does not alter the amino acid isoleucine at codon 432.
In addition, smFRET studies with the MutL(D58A) substitution mutation that does not bind ATP [5], displays no significant changes in FRET efficiency (Figure S1).
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