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When they sequenced it, they found the mutation that destroyed its function.
Of the 54 identified addition genes, 9 were caused by a point mutation that destroyed the stop codon and 45 were caused by a frameshift mutation upstream of the stop codon.
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The known A→G transition mutation that destroys an AflIII restriction enzyme recognition site was detected by RFLP analysis.
Duplicated genes give organisms the opportunity to "experiment" with mutations without losing the biological function of the original gene because when one copy experiences a deleterious mutation that destroys its function, the other copy can still be functional.
A previous study [ 18] has shown that in a spatial replicator system with complex formation, a deleterious mutation that destroys both catalytic and template activity of replicators imposes a great disadvantage to parasitic replicators because of the effective dilution of the system by inert molecules.
Unlike traditional genetic links to disease, the variants are not mutations that destroy a gene's function.
It is caused by mutations that destroy the function of a gene that is needed to make T cells, a class of white blood cells.
Most of the 13 mutations that destroy interactions with both Nse1 and Nse4 change residues that are buried inside the Nse3 molecule (Fig. 3A).
These models yield different consequences of mutations that destroy splicing sites.
Mutations that destroy promoter or regulatory sequences can result in the "silencing" of transcription or translation or premature termination of protein synthesis [ 4].
Some hyper-IgM patients carry mutations that destroy the catalytic activity of AID with a resulting loss of both Ig class-switch recombination (CSR) and somatic hypermutation.
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CEO of Professional Science Editing for Scientists @ prosciediting.com