Sentence examples for mutation that destabilizes from inspiring English sources

The binding of FLNa (I2144E), containing the point mutation that destabilizes the IgFLNa20 IgFLNa21 interaction, was also assessed.

For example, in the case of the c-MYC proto-oncogene, a single nucleotide mutation that destabilizes the G-quadruplex structure in the promoter region leads to a three-fold increase in basal transcription levels, suggesting that the G-quadruplex acts as a transcriptional repressor element [ 27].

A U→C mutation that stabilized the stem-loop structure locked the mRNA in a non-translatable configuration, while a C→A mutation that destabilized the stem-loop structure permitted ShuA translation even at low temperatures.

Thus, an EF-Tu interface mutation that destabilized its interaction with Tyr-T1 tRNATyr during decoding would be expected to increase its rate of release and thereby show a faster kpep.

Mouse hepatitis virus genomes containing three or four nucleotide mutations that destabilize either S3 or S4 were viable, whereas genomes carrying these mutations in both S3 and S4 were not viable.

While several of these maladies are associated with mutations that destabilize the native TTR quaternary and/or tertiary structure, wild-type TTR amyloidogenesis also leads to the degeneration of postmitotic tissue.

The simian primate lineage might have acquired mutations that stabilize the interface, whereas the murine lineage might have accrued mutations that destabilize the interface.

Mutations that destabilize the dimer interface produce extremely large oligomers that can rearrange to form long-lived complexes with a model client protein.

Several mutations that destabilize the native structure of HγD-Crys have been identified that are directly responsible for congenital cataracts (Pande et al., 2000, 2001, 2005).

That is, perhaps this conformation crystallized is not the single 'stable' conformation for the apo-state in vivo and thus mutations that destabilize it have only a minimal effect on activity.

Because many proteins that localize to specific organelles must fold correctly in order to be trafficked properly, mutations that destabilize the correct fold can lead to improper subcellular localization.