Sentence examples for mutation that deletes from inspiring English sources

We report a viral insertion mutation that deletes the putative deacetylase domain, while preserving the N-terminal portion of the protein.

Importantly, rad52-329, a mutation that deletes the C-terminal domain of Rad52 that interacts with Rad51 and permits it to execute its recombination mediator function also has stimulatory effects [38], [39], [40], [41], [42].

The ITPR1opt/opt mouse model (see Figure 1b) shows reduced IP3R1 protein levels on Western blot, but has a mutation that deletes the preferred PKA phosphorylation site Ser-17555) [ 4, 100] in neuronal IP3R1, and therefore violates (iv).

Therefore, we examined whether sacy-1 (RNAi) could suppress germline feminization and self-sterility caused by the tra-2 (e2020 ) dominant mutation that deletes GLD-1 binding sites within the tra-2 3′-UTR (Jan et al. 1999; Clifford et al. 2000).

An increase in the rate of mitotic homeologous recombination was also seen for a truncation mutation that deleted the C-terminal 200 amino acids of Sgs1, which contains the Mlh1 interacting domain [63], [64], suggesting that the interaction with Mlh1 may be important for the suppression of mitotic homeologous recombination [62].

The initiation of cotyledons vs. SAM is largely independent, as evidenced by mutations that delete the SAM but not the cotyledons [ 2, 3] and vice versa [ 4, 5].

The ryT2 pair produced mutations that deleted a short distance into the binding sites on both sides, suggesting that the 26-module TALEN did not block degradation or joining.

In detail, mutations that delete the C-terminus of eIF3h compromise translation reinitiation on mRNAs containing upstream open reading frames (uORFs), and also increase the polysome loading of mRNAs with long 5′ leader or coding sequences [ 20, 21, 24, 25].

We obtained a strain harboring a predicted null mutation, ubc-25 (ok1732 ), that deletes the conserved ubiquitin-conjugating domain.

Primers were designed to replace the glutamic acids at postions 201 or 202, and aspartic acids at positions 159 and 248 with alanine while introducing a silent mutation in the expression vector that deletes a restriction site.

Compared with the numbers of inactivating mutations expected per gene given random accumulation of mutations (fig. 5), there is an overrepresentation of genes with exactly one inactivating mutation, which may reflect large deletions masking mutations that occurred in deleted regions.