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Since men have only one X chromosome, natural selection can speedily promote any advantageous mutation that arises in one of the X's genes.
Prior theories analyzed the evolution of redundant control architectures by the balance between improved performance for additional redundant control weighed against the decay by germline mutation that arises in characters with overlapping function.
This is because it is unlikely that a deleterious mutation that arises within a host could rapidly sweep to fixation in that host once the intrahost viral population is large.
However, we note that if there are a large number of weakly beneficial mutations, it is possible the first successful lineage to appear will be outcompeted by a stronger uphill mutation that arises later but fixes first.
For any particular mutation that arises on the beneficial background, r = 0 is (almost) always optimal (blue curves in Figure 1 and Figure 2; see Figure S3D for an exception).
We document a functionally relevant S1/S2 mutation that arises when FIP develops in a cat.
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Mutation that arose long ago may be key to humans' unique ability to produce and understand speech.
All non-Africans share a mutation that arose in the ancestors of the first people to leave the continent, for instance.
The dcl4-10 mutatisn is a previously unpublished mutation that arose in an EMS mutagenesis [16].
Sandy mice have an autosomal recessive coat color mutation that arose spontaneously in the inbred DBA/2J strain.
We also documented a functional S1/S2 cleavage site mutation that arose in an asymptomatic cat that subsequently developed FIP.
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