Sentence examples for mutation that altered from inspiring English sources
The first of these – the cognitive revolution – was the real game-changer; a genetic mutation that altered the inner wiring of Homo sapiens, enabling them to think in unprecedented ways and to communicate in an altogether new type of language which could not only convey information but also create imagined worlds.
In six patients, the cause turned out to be a point mutation that altered the Bcr-Abl enzyme, allowing it to evade the drug while still retaining the kinase activity that drives tumor cell growth.
This type of resistance was found to be associated either with decreased TopIIα expression or with a mutation that altered the interaction of the enzyme with the drug or DNA [ 9]. High TopIIα expression has been observed in many kinds of cancers, including breast cancer and NSCLC [ 10- 13].
Most examples of antibiotic resistance in pathogenic bacteria are not the result of a mutation that alters the protein that the antibiotic attacks, although this mechanism can occur.
Scn8a med is a loss-of-function allele (29), and Scn8a med-jo is a missense mutation that alters the voltage dependence of activation and inactivation (32).
The most severe allele, tra1- SRR3413 is a triple alanine scanning mutation that alters the serine-arginine-arginine residues found at positions 3413 to 3415.
It represents a linker domain mutation that alters trafficking of the propeptide to early endosomes [ 29] and causes dysregulated proteostasis [ 30].
A specific example was a somatic mutation that alters the DNA-binding motif of transcription factor YY1 found in 14 patients with insulin-producing adenomas.
Shortly thereafter, mutations that altered the function of the sclerostin (SOST) gene were also associated with altered human bone mass.
Sequencing evolved receptors revealed that each contained multiple mutations that altered the amino acid sequence.
To validate whether these encounters are fruitful or futile, we examined three groups of mutations that altered the encounter.
