Sentence examples for mutation that abrogates from inspiring English sources

A mutated protein bearing a Q419K mutation that abrogates activation of Kef by GSH adducts was used to measure background binding.

Furthermore, the same 3-bp substitution mutation that abrogates ATF4 activation dramatically reduced PTH-dependent activation (Fig. 7J), indicating that this element is critical for the actions of PTH on this promoter.

A mouse strain, wrinkle-free (wrfr), containing a spontaneous mutation that abrogates Fatp4 expression, and Fatp4-KO mice display features of lethal dermatology, such as tight, thick, shiny skin and a defective skin barrier, and die shortly after birth, symptoms that are strikingly similar to those of a human skin disease called restrictive dermopathy [3], [4], [5].

The 1100delC variant is a protein truncating mutation that abrogates CHEK2 kinase activity [ 20].

We observed that the K191S mutation that abrogates ATP binding showed similar mRNA binding compared to the wild-type protein.

CHEK2 1100delC, a truncating mutation that abrogates the kinase activity of the protein, confers an approximately 2-fold increase in breast cancer risk [ 8, 13- 15].

Second, we showed here that a Tat mutation that abrogated RNA binding slowed P-TEFb release and, importantly, addition of excess of 7SK RNA to release reactions with wildtype Tat blocked the ability of Tat to release P-TEFb.

A mutagenesis and biochemical study performed on E.coli Ffh revealed a subset of mutations that abrogates the effect of the SRP RNA and results in targeting defects in vivo [31].

Pseudogenes harbor premature stop codons, deletions/insertions, and mutations that abrogate their translation into functional proteins.

For instance, BCL-2 mutations that abrogated binding of BH3 mimetics mediate resistance of ABT-199 in experimental lymphoma models [240].

Previous reports targeting HCV and HIV have suggested that lhRNAs (>50 bp) can adequately inhibit targets harboring mutations that abrogate the silencing efficiency of 21 bp shRNAs [24], [30], [33].