Sentence examples for mutation that abolishes from inspiring English sources

"It has been very hard to find a mutation that abolishes aging," Dr. Rose said.

Therefore, the expectation was that a mutation that abolishes S411 phosphorylation might result in a termination defect.

MC1061 has the spoT1 mutation, that abolishes the ppGppase activity of SpoT and results in increased levels of (p ppGpp (Cashel, 1996).

On other hand, MDM2 mutant with point mutation that abolishes its E3 ubiquitin ligase function (MDM2 Ser440) induced PIR nuclear localization similar to the wild type molecule.

In a recent study, a mutation that abolishes DNA binding (N51S) was introduced into the homeodomain of another leukemogenic NUP98 fusion, NUP98-HOXD13, and its effect on the gene expression profile in mouse hematopoietic cells was examined.

Secondly, to check whether Mia1p-MutNES4 mutant protein could, in principle, interact with Alp14p in vivo, we introduced a pim1-1 temperature-sensitive muthaton thabolisheshes function of the RanGEF, Pim1p, at 36°C [11] into mia1-mutNES4, mia1Δand wild type cells expressing Alp14p-GFP.

However, a mutation that abolished the initiation codon of uORF3 increased FFL activity 1.8-fold.

In contrast, a mutation that abolished the first uORF decreased the effect of mutations in the following uORFs.

It would also be interesting to explore how a knockin mutation that abolished TRPM6/TRPM7 kinase function affected phenotype and channel activity.

Interestingly, this dominant-negative phenotype was rescued by over-expression of BACH1 carrying a second mutation that abolished interactions between the mutant BACH1 and BRCA1.

Mutations that abolished CED-4 oligomerization inactivated its ability to activate CED-3.