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Recently, we investigated the cost reduction of mutation testing based on the identification of sufficient mutation operators [28].
Eligibility criteria for BRCA1 and BRCA2 mutation testing based on family history and age of onset will identify only a small proportion of mutation carriers.
These were used to estimate each woman's probability of carrying a BRCA1 or BRCA2 mutation given her personal and family history of cancer and mutation testing, based on the Boadicea computer program [ 9].
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This work reports an evaluation of classification models to probe the mutagenic activity of α, β-unsaturated carbonyl compounds over two endpoints – the Ames and mammalian cell gene mutation tests – based on linear discriminant analysis along with the topological Substructure molecular design (TOPS-MODE) approach.
Indeed, current mutation screening tests based on the hotspot codons 12 and 13 are likely to result in the mis-classification of up to one-third of patients.
These include phenotypic culture based methods, tests for gene mutations and tests based on bacteriophage replication.
Antiviral therapy can be guided by viral drug susceptibility testing based on screening for known resistance-inducing mutations in the viral genome.
This Salmonella reverse mutation test is based on histidine dependence and mutations in S. typhimurium MTCC-12511, IMTEChandigarhgarh, India).
This Salmonella reverse mutation test is based on histidine dependence and mutations in Salmonella typhimurium (TA98/ MTCC 1251, IMTECH, Chandigarh).
Differences in mutation counts were assessed using the χ2 test based on the assumption that mutation would not show a species preference.
MitoKor is creating a diagnostic test based on the mutation assay.
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