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In TRYPHAENA, generally, numerically lower pCR rates were observed in patients with tumors carrying any PIK3CA mutation tested for, although this did not reach a statistically significant level.
It also demonstrates the potential of this method for screening the BRCA1 and BRCA2 genes as every mutation tested for was readily detected.
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10 Despite the availability of BRCA gene mutation testing for over a decade and increasing knowledge about related cancer risks, only 5% of the carrier population has been identified.
The report should state the methodology and specify the gene, exons and/or mutations tested for.
Four mutations tested for kinase activity in vitro by Sodha et al. [ 27] were included to validate the assay.
This paper uses mutation testing for evaluating an automated static analyzer.
Such pieces of work either customise the mutation testing for AO programs, apply the criterion as a way of assessing other testing approaches, or describe a tool.
This implies that mutation testing for prediction of EGFR treatment response may be restricted to KRAS and BRAF in elderly (>70 years) patients.
The paired t-test was used to compare the time to diagnosis using standard TB cultures with the time to diagnosis by rpoB mutation testing for those patients who had values for both.
Mutation testing for LS includes both sequencing and MLPA.
Mutation testing for BRCA1 and BRCA2 mutations was performed as reported previously (Loughrey et al, 2008).
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