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Exact(12)
And yet in the US most women who test positive for this mutation tend to have an oopherectomy, while many fewer opt for a mastectomy.
Simulations with a disease allele at intermediate frequency, presumably representing an old mutation, tend to exhibit the largest noncentrality parameter values at markers near the disease locus.
As organisms move away from the optimum the effect of the mutation tend to have bigger effect if Q>1 and smaller effect if Q<1.
This is consistent with clinical studies demonstrating that the allelic ratio of the JAK2 V617F mutation does not account for the clonal hematopoiesis in many ET patients [42], and that ET patients with the JAK2 V617F mutation tend to have PV-like features [43].
Neoplasms in women with a germline BRCA1 mutation tend to be ER− (Phillips, 2000).
It may well be that glial tumor cells with IDH1 mutation tend to correct their energy production through the TCA cycle by overexpressing LDHB.
Similar(48)
Moreover, patient carriers of a post-zygotic mutation tended to have a higher total sALP level than non-mutated patients, but lower than patients with a germinal mutation.
Patients with the KRAS mutation tended to do worse after gemcitabine-based or pemetrexed-based chemotherapy (RR 14%% mutation vs. 28%% in wild type) [21].
However, the adult-onset mutation tended to increase the complexity of the distal axonal arbor.
Note that the use of the yw background is far from being ideal (the y mutation tends to make flies more susceptible to infection).
Similarly, P96S mutation tends to generate more freedom for Switch I to swing, which is also unfavorable for nucleotide binding and hydrolysis (Fig. 3b).
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