Sentence examples for mutation targets the from inspiring English sources

This mutation targets the tyrosine kinase domain of the neurotrophin tyrosine kinase receptor (Fig. 2).

We conclude that the gltA2-R mutation targets the gltA promoter, and that the fitness effects of this mutation result from reduced gene expression.

Functional characterization of this patient FMR1 allele reveals that the mutation targets the protein to the nucleolus in cultured human and mouse cells.

If a second mutation targets the intact RB gene in a cell of the retina, tumor suppressor function is deleted and a tumor will arise.

The cause of the disorder is a genetic mutation targeting the cystic fibrosis transmembrane conductance regulator (CFTR) gene.

Interestingly, response was linked to the presence of an activating somatic mutation targeting the tyrosine domain of EGFR [ 15- 17].

Another mutation targeting the S-helix has been observed in the terminal heptad of the receptor guanylyl cyclase GC-A [ 28], wherein a leucine is substituted by an arginine.

Second, more extensive mutations targeting the central appendage either completely disrupted (ΔLQPNP) or reduced (EndoA(Arf -HA) the in vivo function of endophilin-Arf -HA

In conclusion, mutations targeting the central helix-loop appendage on the dEndoA-BAR domain can severely depress survival and spontaneous motor activity of adult flies.

Several of the mutations targeted the essential peptide-binding surface of the BRCA1 BRCT domain.

Mutations targeting the Bub3 interface prevent kinetochore recruitment of the SAC kinase Bub1.