Sentence examples for mutation targeting of from inspiring English sources

Mutation targeting of the RNAP initiation complex is not linked to the ability of the deaminases to bind RNA per se, as the catalytic C-terminal domain of APOBEC3G in this study is inert regarding RNA binding.

Interestingly, response was linked to the presence of an activating somatic mutation targeting the tyrosine domain of EGFR [ 15- 17].

Anderson, G. R. et al. PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation.

Anderson, GR, Wardell, SE, Cakir, M, Crawford, L, Leeds, JC, Nussbaum, DP, Shankar, PS, Soderquist, RS, Stein, EM, Tingley, JP, Winter, PS, Zieser-Misenheimer, EK, Alley, HM, Yllanes, A, Haney, V, Blackwell, KL, McCall, SJ, McDonnell, DP, and Wood, KC. "PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 tranScience Translational Medicinel Medicine 8, no.

Inactivating mutations targeting all copies of one gene may result in loss of functional redundancy of a second gene implicated in the same essential biological pathway.

This mutation targets the tyrosine kinase domain of the neurotrophin tyrosine kinase receptor (Fig. 2).

This mutation abrogates the targeting of MHC I molecules to endolysosomal compartments where they may undergo peptide exchange and acquire exogenously derived antigens for cross-presentation [5], [6].

Alterations include recurrent mutations targeting core components of the nuclear co-repressor complex (NCOR1, TBL1XR1, and GPS2) and the nuclear co-repressor 2 (NCor2) or SMRT.

Analysis of the spectrum of mutations showed that targeting of A residues within WA motifs was significantly impaired in Msh2−/−Msh6−/− mice (Figure 4).

Thus, disruption of the Myo1 motor domain by kidney-disease-associated mutations resulted in targeting of Myo1 to eisosomes.

They also may include haploinsufficient tumour suppressors, whose partial loss of function contributes to cancer development in the absence of mutations targeting the second wild-type allele4.