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Group C (n = 16): breast cancer patients with BRCA2 mutation; surgery during the period 1984 2009.
Group B (n = 19): breast cancer patients with BRCA1 mutation; surgery during the period 1984 2009.
The patients considered for inclusion in this study were female patients who had been treated with breast surgery in Skåne County and met the criteria for one of the following groups: Group A (n = 30): breast cancer patients without BRCA1/2 mutation; surgery during the period 1999 2006.
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Botkin JR, Smith KR, Croyle RT, Baty BJ, et al. Genetic testing for a BRCA1 mutation: prophylactic surgery and screening behavior in women 2 years post testing.
These findings indicate that knowledge of a BRCA1 or BRCA2 mutation before definitive surgery significantly increases the number of women opting for bilateral mastectomy for both treatment and risk reduction [ 26, 66, 67].
Because distant metastases is what eventually kills patients, it would be of interest to learn whether it is KRAS mutation status or undergoing liver surgery per se that changes the course of the disease.
van Oostrom I, Meijers-Heijboer H, Lodder LN, Duivenvoorden HJ, et al. Long-term psychological impact of carrying a BRCA1/2 mutation and prophylactic surgery: a 5-year follow-up study.
Many studies assessed the potential prognostic impact of several somatic mutations including KRAS, BRAF, and TP53 mutations after curative surgery 34– 34.
Additionally, 2/9 dogs with c-KIT mutations treated with surgery alone survived greater than 20 months.
Kiran Dhillon (@Indigal9), a postdoctoral researcher at Fred Hutchinson Cancer Research Center, started blogging about her breast cancer work when Angelina Jolie spoke about inheriting a BRCA mutation and having prophylactic surgery.
Consistent with her germline mutation, hypertension recurred after surgery, requiring reinstitution of treatment.
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