In one study, none of the 38 patients was found to have mutated K-ras, and in another study two of 23 patients had a mutation suggesting that mutations in kras are exceedingly rare [ 31, 32].
One contained a mutation, suggesting that it was Clock.
In one sample, the MUTYH mutation was associated with a MSH6 disease-causing mutation, suggesting that this method is helpful to identify additional cancer risk modifiers and provides a useful tool to optimize clinical issues.
In this study, 62.7% of patients with transitional cell carcinoma had a p53 mutation, suggesting that the p53 gene mutation may be used as a marker of transitional cell carcinoma.
When the researchers further tested the families with a single case, they found that the parents did not have the mutation, suggesting that the mutations were not inherited but had arisen spontaneously in mom's egg or dad's sperm.
However, severe DCM developed with the addition of a transgene encoding a DCM mutation, suggesting that the mutant transgene encodes a protein with dominant negative activity.
Furthermore, both host mutants show efficient suppression of the cIII mutation, suggesting that in the absence of FtsH and HflKC, CIII is dispensable.
For LGII, LGIII, LGIV, LGV and LGX (Figure 4), the 93 recombinants were distributed according to normal Mendelian segregation for a recessive mutation, suggesting that the glp-4 mutation is unlinked to any of these chromosomes.
Our data also demonstrate an incremental increase in the lens γ-crystallin peak fraction with the αB-R120G mutation, suggesting that αB-crystallin may affect the expression of γ-crystallin.
In one case, transgenic expression of Gabrb3 from a neuron-specific enolase promoter failed to complement the cleft plate phenotype of a Gabrb3 null mutation, suggesting that non-neural expression of Gabrb3 was required for normal palate formation [10].
For LGI, LGII, LGIII, LGIV, and LGX (Figure 6a), the 93 recombinants were distributed according to normal Mendelian segregation for a recessive mutation, suggesting that the epa-18 mutation is unlinked to any of these chromosomes.
