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In silico analysis of the p.P49L mutation suggested that it could have functional effects.
The major p53 mutation suggested that reactive oxygen species are not likely involved in gene mutations of Thorotrast ICC.
More recently, research on the Arabidopsis ibm1 mutation suggested that novel transcription-coupled mechanisms direct gene body methylation [39], hence such RdDM-independent target methylation mechanisms might exist in plants.
In addition, the evidence of the increased nuclear localization of VHL-UbΔGG with lysine 196 mutation suggested that the regulation of lysine 196 is involved in controlling the process of VHL nucleus –cytoplasm shuttling, and that this regulation may be associated with PIASy interaction since we observed that VHL-UbΔGG interacts with PIASy in our previous studies [32].
The absence of this mutation suggested that these tumors were good candidates to harbor driver mutations elsewhere.
The combined influences of host type and population size (e.g., efficiency of selection) on forward/back mutation suggested that these alleles governed host-specific growth performance.
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The Playlist this week reported comments from Noomi Rapace, the only human member of the crew of the Prometheus to survive the movie intact and without obvious mutations, suggesting that process is finally under way.
The independent distribution of these different PAE mutations suggests that, as would be expected, these mutations arise separately of each other.
This effect was not seen in strains carrying a uvr mutation, suggesting that DNP interferes with the excision repair process.
The (ΔpolA mutation acted synergistically with the recF mutation, suggesting that the polA gene functions in pathways of postreplication repair that are largely independent of the recF gene.
The identification of the oscillator mutation suggests that severe loss of function alleles in humans would result in prenatal or neonatal lethality.
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CEO of Professional Science Editing for Scientists @ prosciediting.com