Sentence examples for mutation study revealed from inspiring English sources

Our mutation study revealed that hARD1 associated with an IgG motif of MLCK and acetylated the Lys608 residue in this motif.

Furthermore, Boyden chamber experiments showed that tumor cell migration and invasion were significantly inhibited by hARD1, and our mutation study revealed that hARD1 associated with an IgG-C2 motif of MLCK and acetylated the Lys608 residue in this motif.

A mutation study revealed that E. coli TmcA strictly discriminates elongator tRNAMet from the structurally similar tRNAIle by mainly recognizing the C27 G43 pair in the anticodon stem.

Furthermore, recent germline mutation study revealed that polymorphic deletion of BIM in Eastern Asian is common and BIM has a central role in Gefitinib-induced apoptosis in NSCLC harboring activating EGFR mutations.

Recent large-scale somatic mutation studies revealed that SPOP is one of the most frequently mutated genes in human prostate tumors (Barbieri et al., 2012; Kan et al., 2010).

In addition, MD simulation and mutation studies revealed key residues for inhibitory potency and selectivity, which provides a guideline for further drug design against obesity, diabetes and atherosclerosis.

In mammals, important amino acid motifs involved in receptor binding have been identified and mutation studies reveal the importance of the N-terminus [ 20].

Because of genetic redundancy and overlapping expression patterns of the MEF2 genes, interrogating individual MEF2 gene activity in mammals has been experimentally challenging, with loss-of-function mutation studies revealing only limited insights into MEF2 gene function in tissues in which the MEF2 genes do not overlap/compensate.

65, 66 In iPSC-derived CMs produced from two patients with KCNQ1R190Q mutation, 69 functional study revealed a dominant negative trafficking defect associated with a 70% 80% reduction in IKs alongside altered activation and deactivation properties of KvLQT1.

In the three classical genetic model organisms Drosophila melanogaster, Saccharomyces cerevisiae, and Arabidopsis thaliana, mutation accumulation studies revealed mutational biases pushing their genomes toward high equilibrium A/T contents.

The study revealed that mutation of Lys487 resulted in ∼95% loss of the activity thus demonstrating its crucial requirement for the enzymatic activity.