Structure modeling and site-directed mutation study indicated that Ser51 in SCF-4 involved in the binding of enzyme with glyphosate and played a crucial role in the improvement of catalytic efficiency.
Using human cancer cell lines expressing p53 with various lysine to arginine mutations, these studies indicate that K120R, K164R as well as K120/164R double mutations partially impaired the p53-dependent functions (Sykes et al., 2006; Tang et al., 2006; Tang et al., 2008).
Our studies indicated that mutation of T1410 can influence GTP hydrolysis, but with no gross effect on GTP binding, although we cannot discount more subtle effects on its binding properties [74].
Previous studies indicated that mutation of the P0 gene affects ribosome activity and cell viability in Saccharomyces cerevisiae [ 21].
Previous studies indicated that mutations of E45K in the first transmembrane domain (TMD), and K404L in the 11th TMD, produce selective and opposite alterations in binding of natural folate substrates to murine RFC.
Previous studies indicated that mutations in the EYA gene were associated with postlingual, progressive, autosomal dominant hearing loss at the deafness [ 16].
The above studies indicated that mutations in GHR could lead to the obstruction of normal human and animal skeletal muscle growth and fat deposition by causing GH signal transduction obstruction.
Several recent studies indicated that mutations in CA as well as small molecule compounds targeting CA can affect reverse transcription and nuclear import (reviewed in Matreyek and Engelman (2013)), disfavoring the model of immediate capsid dissociation.
Molecular dynamic simulation studies indicated that the mutation decreased the subunit binding energy and modified the distribution of surface electrostatic potentials.
Some studies indicated that the mutation of promoter and exon 1 in MBL genes may lead to the decline of serum MBL level, while a lower serum MBL level can reduce tubercle bacilli infections [ 18, 19].
