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In E. coli lacking MutH, MutS, and MutL proteins, forward mutation studies in the lacI gene showed a 200-fold increase in mutation rate [32], [44], [45].
The latter is also consistent with recent mutation studies in Kv channels [4], [33], as well as in Ca+2 activated channels [34] where its linker was also shown to regulate ionic currents.
(c) Packing perturbation and cysteine mutation studies in S4 suggest that KCNE1 lodges at the inter-VSD S4-S1 interface between two adjacent subunits and thereby affects Kv7.1 sensor functions.
The regulatory effect on chondrocyte differentiation was verified by gene mutation studies in mice.
Motif mutation studies in rats have indicated that nuclear respiratory factor 1 (NRF-1), NRF-2 and Sp1 promote basal Tfam gene transcription.
Mutation studies in Lotus japonica have indicated that at least seven genetic loci control the early stages of establishing both AMs and nodulation (Kistner et al. 2005).
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This is the first report of a COL7A1 mutation study in DEB from Korean patients.
However, mutation study in E. coli [ 56] suggested that in this particular position the side-chain length is not important, and a positive charge is "simply" required.
Further GWAS and causative mutations studies in the autosomes might be done in the future in order to identify more informative variants for these traits.
Studies evaluating fibroblasts for loss of heterozygosis and point mutations, studies in cell culture or animal models or other diseases than breast cancer and studies without reference to the nodal status of patients were also excluded.
The hydrophobic residues selected for mutation studies described in Figure 3 and onwards are labeled with corresponding colors.
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