Sentence examples for mutation studies for from inspiring English sources

For a comparative structural model of peptidase HtrA from Helicobacter pylori, we performed mutation studies for predicted hot-spot residues, which were confirmed as functionally relevant for HtrA activity or oligomerization.

These observations support our site-directed mutation studies for both the PHD1KDM5B protein and the H3K4me0 peptide (Table S1).

These models were validated using transcriptomic data from the existing literature and two independent mutation studies for tra [ 17] and dsx (presented here).

The discrepancy between the reported rate of mutation and LOH raises a number of questions, including the accuracy of the reported mutation studies, the potential for other mechanisms of gene silencing (such as, promoter methylation or other epigenetic event), or the possibility that a second gene target lies in the region.

In addition, MD simulation and mutation studies revealed key residues for inhibitory potency and selectivity, which provides a guideline for further drug design against obesity, diabetes and atherosclerosis.

ESTs are potentially very valuable for mutation studies since they represent cloned single alleles, but are also unverified sequences, with a high rate of sequencing errors [19], [20].

Knowledge of cancer genomic DNA sequences has created unprecedented opportunities for mutation studies.

Combining these results with independent large effect mutation studies, allows clear candidates for detailed molecular follow-up to emerge.

The hydrophobic residues selected for mutation studies described in Figure 3 and onwards are labeled with corresponding colors.

Coding sequences of human GAD65, GAD67 and GAD catalytic loop-swap enzymes (GAD67Tyr292Phe_65loop and GAD65Phe283Tyr_67loop) were cloned into pCR® blunt and used for mutation studies.

On this basis we suggest that possible target sites for future mutation studies could include Ser357 or Thr356 (Ala236 or Ile235 for Dd), all of which are nonconserved and in close proximity to the cubane cluster.