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The role of B-Raf mutation status remains unclear.
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Thus, the prognostic value of KRAS mutational status remains controversial.
However, what the role of BRCA1 methylation, basal-like and BRCA1-mutation status is remains unclear due to small numbers.
However, even among patients who are selected for specific treatments based on their somatic EGFR mutation status or EGFR expression profile, there remains a notable lack of response to EGFR-targeted therapies in a significant portion of the patient population.
We assume that the sensitivity correlates with the p53 mutation status or with the SIRT1/2 expressions, this remains to be further investigated.
Hence, it remains to be shown whether KRAS mutation status predicts treatment response in GC patients.
Thus, the possibility remains that heterogeneity of the KRAS mutation status could be the cause of altered cetuximab/panitumumab efficacy.
It is worth noting that the driver versus passenger status remains formally untested for most cancer-associated mutations.
The meaning of c-MYC gain according to KRAS mutation status could not be sufficiently analysed owing to low KRAS mutation rate, and it remains to be clarified further.
Although this previous study detected NPC2 secretion from human lung adenocarcinoma cell lines (Taguchi et al, 2011), it remains unclear if NPC2 secretion levels could be altered by the oncogenic mutation status and/or disease progression.
22 Despite the landmark discovery of the relationship between KRAS mutation status and response to anti-EGFR antibodies, the response rate in KRAS wild-type (KRAS-WT) chemo-refractory patients remains in the order of 20%.
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