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The present study does not allow for differentiating between effect modification by mutation status on the one hand and inherited differences with respect to fertility or problems with breast feeding due to presence of the mutation on the other.
Here, we report the effect of TP53 and CHEK2 mutation status on response to paclitaxel.
A meta-analysis may help to clarify the effect of mutation status on survival.
Geographical variations may also explain the differences in the impact of mutation status on prognosis.
Two studies [ 4, 7] found no effect of TP53 mutation status on response to taxanes.
It would have been optimal if we had had mutation status on all participants in the study.
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However, adding information on mutation status of PIK3CA and loss of PTEN does not add significant prognostic information.
The relevance of the findings reported in the article on mutation status of PIK3CA, PTEN, KRAS and BRAF, and correlation between expression levels of epidermal growth factor receptor (EGFR) and cetuximab-mediated antibody-dependent cell-mediated-cytotoxicity (ADCC) published in September 2011 is now in question.
Although these cases differed from cases with known KRAS-mutation status on several factors that could be related to prognosis, we obtained point estimates similar to those in our primary analyses in sensitivity analyses using multiple imputation to account for these missing data.
Thus, information on mutation status for high penetrance breast cancer genes is not available.
DFA CV1 values were significantly different between cells based on mutation status for all comparisons (Wilcoxon P-values 0.00005 0.01, Table 1, Figure 2).
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