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For example, when a network area with enriched number of mutated genes is located, the corresponding mutation matrix can be retrieved to investigate mutation status for these genes in individual samples.
In colorectal cancer (CRC), the molecular characterization of RAS and BRAF mutation status for prognostic and predictive purposes is commonly performed by different validated methods.
Mutation status for GNAQ/ GNA11 will be assessed retrospectively.
Thus, information on mutation status for high penetrance breast cancer genes is not available.
The clinicopathologic characteristics and mutation status (for the BRCA1-associated and BRCA2-associated tumors) are summarized in Table 1.
IDH1 and IDH2 mutation status for these tumors was identified using the cBioPortal for Cancer Genomics (http://www.cbioportal.org/public-portal/).
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CIMP status and mutation status of BRAF and KRAS for each tumor sample was previously determined [5].
Many of these trials did not test for EGFR mutations systematically, therefore, their results are reported either for all randomized patients, ignoring EGFR mutation status, or for the subset of patients in whom the status was known.
Only 9 of 30 (30%) patients had BRAF mutation status available for this combination treatment involving a MEK inhibitor.
Two hundred colorectal cancers from FFPE tissue previously characterized for KRAS mutation status were evaluated for PIK3CA mutations.
As mentioned above, removing TP53 mutated tumors including the double-mutated Epi203 from statistical analysis, CHEK2 mutation status still predicted for resistance to anthracycline therapy.
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