Sentence examples for mutation status even from inspiring English sources

For example although ER-negative status clearly predicts BRCA1 mutation status, even ER-positive BRCA1-related breast cancers are more likely to be grade 3, CK14+, and show high mitotic rate compared with ER-positive sporadic cancers [ 52].

Nor is it surprising that prophylactic oophorectomy is more frequently discussed with affected women (even if their mutation status is unknown), since it is very likely that they are carriers of a mutation that may also increase their risk of ovarian cancer.

Pyrosequencing provided sufficient analytical sensitivity and specificity to assess the mutation status in routine formalin-fixed CRC samples, even in tissues with a low tumor cell content.

Furthermore, for the oncologist, it is important to know whether BRCA1/2 mutation status is an independent prognostic factor, or even a predictive factor, which should be taken into consideration when decisions about treatment are taken.

However, we envision that new techniques for analysis of additional aspects such as histone modification states and gene mutation status will reveal mechanisms that would explain even more gene expression changes within individual samples.

Among the candidate genes of the significantly deranged pathways, we identified VEGFA expression as an important marker of survival even when controlled by TP53 mutation status.

Vascular endothelial growth factor A (VEGFA) maintained significance in multivariate model (Supplementary Table 7), even after adjusting for TP53 mutation status.

Table 1 also shows that, in contrast to family history features, most morphological features studied were individually predictive of BRCA1 mutation status, with four having smaller P-values than even the most significant family history feature.

There was no evidence that risk of breast cancer depends on AIB1 CAG/CAA polymorphism status, even if affected women carry a mutation in BRCA1 or BRCA2.

We found no evidence that risk of breast cancer depends on AIB1 CAG/CAA polymorphism status, even if affected women carry a mutation in BRCA1 or BRCA2.

Moreover, we have previously shown that, even without knowledge of germline PALB2 mutation status, minimal sclerosis is associated with about a five-fold increased risk for relatives of women with early-onset breast cancer (Dite et al, 2012).