Sentence examples for mutation status determined from inspiring English sources

Whether KRAS mutation status determined by ARMS/S can be used as a predictive biomarker is not yet known.

The results in that patient encouraged us to hypothesise that the EGFR mutation status determined in pleural effusion fluid is useful for predicting the responsiveness to EGFR tyrosine kinase inhibitors.

The relationship between the EGFR mutation status determined in pleural effusion fluid and the gefitinib response in a portion of the patients enrolled supports the pleural effusion fluid EGFR mutation status as useful for predicting the response to gefitinib.

In conclusion, our results suggest that the DNA in pleural effusion fluid can be used to detect EGFR mutations and that the EGFR mutation status determined may be useful as a predictive factor of response to gefitinib.

In conclusion, our study suggested that KRAS mutation status determined by ARMS/S appeared to be more closely related to clinical effects than that determined by direct sequencing, although there were limitations of sample size and retrospective design.

Although EGFR mutations were detectable by both PCR direct sequencing, which has generally been used to detect the mutations and the Scorpion ARMS method, mutation status determined with Scorpion ARMS predicted response to gefitinib in our study (Kimura et al, 2006).

Of 597 patients with KRAS exon 2 WT tumours and RAS data, 107 (18 %) had other RAS mutations (RAS status determined using bidirectional Sanger sequencing and WAVE-based Surveyor® Scan Kits (Transgenomic) cIncluded only patients with baseline measurable disease per central review Results of the final analysis were consistent with the primary analysis.

Proportions of patients who were referred and were not referred, related to the BRCA1/2 mutation status as determined in our research cohort, were determined and patient characteristics (age at diagnosis of the tumor; family history) were summarized for the different groups.

p53 mutation status was determined by direct sequencing of exons 2 11 of p53 and the p53 protein levels were determined by IHC staining as previously described (Zheng et al., 2013).

BRAF V600E mutation status was determined using pyrosequencing; PCR amplification and mutational analysis were performed as described in the Diatech manual Anti-EGFR MoAb response (BRAF status).

On multivariate analysis (Cox regression), which included histone mutational status, age of diagnosis, histological grade and sex, only histone mutation status was determined to be a significant predictor of overall survival with a hazard ratio of 2.8 (95 % confidence intervals, 1.35 5.78, p = 0.006, Table  2).