Sentence examples for mutation status based from inspiring English sources
Specimens were selected for mutation status based on Sanger and/or MPP.
Lack of estrogen receptor (ER) and progesterone receptor (PR) expression has also been reported to improve prediction of BRCA1 mutation status based on family history.
In the case of erlotinib, this recommendation is independent of mutation status, based on a placebo-controlled, phase III trial in unselected relapsed/refractory NSCLC patients (BR21) [ 6].
This study could not provide a comparison to existing LR estimates of BRCA1 mutation status based on ER-CK status, determined from analysis of 182 BRCandand 109 age-matched cases [ 6].
Lack of oestrogen receptor (ER) and progesterone receptor (PR) expression has also been reported to improve prediction of BRCA1 mutation status based on family history (Lakhani et al, 2002; James et al, 2006; Mavaddat et al, 2010).
Using KEGG, we derived a pathway mutation status based on its gene members (see " Methods") and looked for association with the clinical variables (Table 3; Additional file 6: Table S5 and Additional file 7: Table S6).
However, because not all mutations result in increased expression, we also used TP53-mutation status based on sequencing (for 204 of the 295 patients).
Hence, the evaluation of KRAS mutation status was based on the cycle thresholds (Cts) of the wild-type and mutant amplification curves and on the differences between these Cts (dCts), whereby dCtA = (Ct for mutant target A) - (Ct for DNA control coamplifying with mutant target A).
This study assessing histopathological predictors of BRCA1 and BRCA2 mutation status is based on the largest sample set reported to date, and so provides more-precise estimates that account for age at diagnosis as a potential confounder.
However, potential imbalances in EGFR mutation status were simulated based on tissue results and found to have been unlikely to have biased the results.
To further investigate the clinical relevance of p-PP2A in metastatic CRC we analysed its potential prognostic value by stratifying our cohort based on KRAS mutation status, and we found that p-PP2A retained its prognostic impact in both KRAS wild-type and KRAS mutated subgroups with a similar significance (Supplementary Figure 3).
