Sentence examples for mutation state from inspiring English sources

This database contains 241 human kinases and offers gene information, including the UniProt identifier, mutation state, gene symbol, Entrez identifier, and structural information on kinases, such as the PDB identifier and DFG-in or DFG-out state (Fig. 4a).

a The Curated Kinase Database contains 241 human protein kinases and the UniProt identifier, mutation state of PDB, gene symbol, DFG-in or DFG-out state, etc. b The Kinase Inhibitor Database provides information on 178 kinase inhibitors.

We compared the gene expression between the two end-stage cardiomyopathic hearts reasoning that the differences in gene expression were more likely to reflect the LMNA mutation state.

In Figure 2C we plot curves of nact/N vs. log10y for a number of possible values of p. The curves agree with the expectation that the more informative an F2 animal is about the mutation state of its F1 parent (i.e., the smaller p is), the fewer F2 animals must be examined to achieve a specific value of nact/N.

Next, we assessed TP53 mutation state and protein expression by IHC.

Mutation state or IHC expression level weighted more in decision making whenever one of the three parameters was not available.

Each column represents an individual patient, colour-coded based on copy number aberration (amplification or deletion) and/or mutational state (truncating mutation, inframe mutation, missense mutation) across profiled oncogenes and suppressors frequently altered in lung adenocarcinoma.

Let X → g = X 1 g, …, X J g be the vector of observed non-silent mutation states of gene g for all samples (where X j g ∈ { 0, 1 } and 1 = one or more non-silent mutations anywhere in the gene; 0 = no mutations in the gene).

In order to identify somatic mutations, it is necessary to infer the germline (pre-mutation) state for each observed sequence.

Widespread hypomethylation contributes to a hyper-mutation state in cancer, which may generate oncogenic mutations or loss of heterozygosity of tumor suppressor genes.

The fallopian tube is currently regarded as the most important site of origin of these tumors, the type associated with the BRCA1 mutation carrier state.