Sentence examples for mutation spectrum with from inspiring English sources

Newborn screening has revealed a more varied mutation spectrum, with c.985A > G homozygotes representing from 30%to80%0% of MCADD cases [ 1, 7].

Using this approach, we enriched and sequenced an unprecedented 3872 lacZ mutant plaques from control and BaP-exposed samples in a single sequencing run and established the BaP-induced mutation spectrum with unparalleled precision.

To further test the accuracy of our NGS data, we compared the control and BaP-induced bone marrow lacZ mutation spectrum with published mutation spectra for transgene reporters from control and BaP-treated mice.

Although introns are not expected to have similar patterns of indels to bona fide protein coding genes, because the idea of the psuedogene set was to have a set of indel polymorphisms that reflects the mutation spectrum with as few constraints as possible, including introns was acceptable, as they are expected to have few constraints as well.

Futhermore, these mutants had an unusual spontaneous mutation spectrum, with a predominance of A T to T A transversions, followed by G C to T A transversions and frameshifts generated in runs of adenines in both the +1 and -1 direction.

Using our conservative approach, we identified 1006 independent mutations within the lacZ transgene allowing us to characterize the spontaneous and BaP-induced mutation spectra with unparalleled precision.

In our analysis of EST sequences, mutation spectra with more than 5 mutations were detected for 83 of the 249 cancer-related genes, and 5 of these belonged to the CASPS list.

We have analysed the mutation dynamics of wt MSV isolates (MSV-MatA and MSV-VW), a laboratory-constructed chimaeric MSV and various recombinant viruses emerging during recombination experiments, and compared MSV mutation spectra with those occurring within the related begomovirus species, TYLCV.

These simulations show that sampling around 100 mutants per animal is sufficient to achieve reliable mutation spectra with a power of 80%%, and therefore, pooling approximately 170 mutants per barcode (assuming a mutant recovery of ~60%%) should be more than enough for any sequencing application.

Forty seven mutations were detected by sequencing of p16 exon 2 in 44 BE patients (14.5%) with a mutation spectrum consistent with that caused by oxidative damage and chronic inflammation.

In addition, a slight but not significant modification of the mutation spectrum associated with an increase of G C to T A and A T to C G transversions was noticeable in the treated animals.