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A similar analysis of cyclic therapies, and also of informed therapies where certain aspects of individual patient mutation spectrum are known, is a subject of current and future research.
In this model, tumor morphology and mutation spectrum are also similar to those in human CRC [ 6].
Some genes, e.g., TP53, EGFR, and KRAS, have high frequency of mutations in lung cancer (The Cancer Genome Atlas Research Network, 2012, Imielinski et al., 2012), and ethnic and sex-related differences in mutation spectrum are noted (Dearden et al., 2013, Kosaka et al., 2004).
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This mutation spectrum is consistent with an exposure to PAHs (Smith et al., 2000; see also Figure 6), which are present in substantial concentrations in smoky coal emissions.
The fibroadenoma MED12 mutation spectrum is nearly identical to that of previously reported MED12 lesions in uterine leiomyoma but not those of other tumors.
The mutation spectrum was also altered, with proportionally more C than G mutations [31].
To explore this hypothesis, OncoMap was used to query a series of pediatric low-grade gliomas (LGGs) whose mutation spectrum is incompletely defined.
On the other end of the mutation spectrum is the simple M680I heterozygosity found in one of the healthy volunteers, C6b, which did not result in any clinical or subclinical (cytokine profile) FMF manifestation.
The mutation spectrum was broad with few recurrent mutations in the dataset.
Mutations not previously reported have been detected, indicating that the mutation spectrum is only partly defined.
Consequently, the mutation spectrum was compared with other ethnic groups residing in the Arabic population.
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