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Targeting the epidermal growth factor receptor variant III (EGFRvIII), which is a mutation specific to tumor tissue, could eliminate this risk.
The treatment--so far only examined in test tubes--targets a gene mutation specific to the cancer cells, leaving healthy cells unharmed.
Last year, geneticists scored a major victory when they were able to identify the gene mutation specific to Gavin's type of LCA -- an essential step toward treatment.
Therefore the activation of RET seems to be a somatic cell mutation specific to human thyroid carcinomas.
The BRCA1 5382insC mutation, specific to Ashkenazi and Russian populations, was found twice in our study group, representing a possible founder mutation in the Turkish population.
A major gene or causal mutation specific to each breed (DGAT1 and casein variant) could explain the good results obtained for the within-breed model.
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Overall, we demonstrated the emergence of unique mutations specific to an infected individual and temporal genetic variation during infection.
Well-designed behavioral screens are focused to find mutations specific to a particular neural system.
Passenger mutations specific to particular mouse strains can distort experimental outcomes.
To create the treatment, doctors first cut small pieces of tissue from Perkins's tumours and studied the DNA to find mutations specific to her cancer.
Among mutations specific to the m-PET-high tumor were a gain of function mutation of PIK3CA (T1258C) and a truncating mutation of RB1 (splice site, chromosome 13: 49047536 del).
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