Sentence examples for mutation significant from inspiring English sources

The shift in the pH-dependent equilibrium upon replacing Ala2 with Val, without a change in SH parameters, suggests the side chain of the second residue plays a similar indirect role, however the A2V mutation shifts the equilibrium in the opposite direction (subtle decrease in high pH mode) compared with the D1N mutation (significant increase in high pH mode).

After transfection of additional K-Ras mutations, significant focus formation was observed for codon 117 and 146 mutations.

Among women with germline BRCA1 mutations, significant positive associations were observed between AIB1 alleles of 26 or fewer glutamine repeats and breast cancer risk [ 5].

STAG2, EZH2, and ASXL1 mutations have significant relationships with RUNX1 mutations, 3, 4 suggesting that these mutations may functionally collaborate with RUNX1 mutations.

Our conclusion is supported by kinetic analysis of harmine inhibition as well as by the characterization of a Dyrk1A mutation conferring significant resistance to harmine.

In addition, the strains bearing the fadD mutation showed significant differences in the quantities of free fatty acids found in the broth.

In order to find this rare mutation with significant reproducible results, many family members and matched controls are necessary.

Ectopic expression of CES1 carrying this mutation confirmed significant reduction of its esterase activity in vitro (Zhu et al., 2008).

As expected, hog1 mutation caused significant reduction in expression of all these genes.

The γ3R225W mutation has significant functional effects as demonstrated by increases in basal and AMP-activated AMPK activities, increased muscle glycogen and decreased IMTG.

However, the K1487R mutation caused significant increase of UV-induced Rad53 phosphorylation in rad16 (Fig. 7E and F) and rad16 rad26 cells (Fig. 7H and I).