Sentence examples for mutation showed that from inspiring English sources

Recent in vitro experiments using familial ALS patient-derived induced pluripotent stem (IPS) cells with the M337V TDP-43 mutation showed that astrocytes generated from these IPS cells reveal cytoplasmic inclusions and premature cell death, thereby mimicking histopathological findings of TDP-43 proteinopathies (53).

The most extensively studied DCM-associated toT mutation to date is ΔK210; functional studies of the ΔK210 mutation showed that the mutated protein reduced the Ca2+ sensitivity of actomyosin ATPase activity, which resulted in a decreased maximum speed of muscle contraction [ 30, 31].

The characterization of mW and iP for the protein sequences translated from contigs with non-synonymous mutation showed that the mW from the mutated sequences was altered, but 250 sequences did not demonstrate any changes in iP values.

Control experiments in which 100% of the population contained a specific mutation showed that extension was nearly abolished when mismatches occurred at the neighboring position.

Analysis of dephosphorylation of phosphorylated peptides derived from CDK9's T-loop and also in vivo phosphorylated CDK9 with Ser175 mutation showed that Ser175 could be dephosphorylated by PP1 in vitro.

Our earlier studies characterizing the hi559 mutation showed that the lack of de novo PI synthesis leads to ER stress and hepatic steatosis (Thakur et al., 2011).

More precise expressions that account for finite chromosome numbers and integrate over positions of linked mutations show that s ∼ d is generally no more than 4 s − Δ U h (Johnson 1999b; Lynch 2008).

Furthermore, comparison to tips assembled from the distal domain IpaDΔ192-267 mutation shows that IpaD adopts an elongated conformation that facilitates its ability to control type III secretion and stepwise assembly of the T3SA needle tip complex.

Designed mutation shows that switching interactions enhance the rate, perhaps by destabilizing the ground state immediately before the transition state and limiting nonproductive diffusion before and after the chemical transition state, thereby reducing the activation entropy.

On the whole, these results provide an explanation for the clinical impact of the NGFR100 mutation, showing that the survival functions of NGF in neuronal development are largely unaffected by this mutation.

The absence of the paternally-inherited mutation shows that the fetus will not be a β-thalassaemia major.