Sentence examples for mutation showed reduced from inspiring English sources

Davis [37] also reported that flies carrying a tw mutation showed reduced viability.

A promoter mutation showed reduced in vitro activity corresponding to lower mRNA expression in patient samples.

Correspondingly, cells carrying the Ubp3S695A mutation showed reduced binding of RNA Pol II to STL1 and CTT1, promoters and coding regions, compared with the WT.

The Usp binding site in FoxO protein was identified and FoxO NK mutation showed reduced binding affinity to Usp. (A ) Point mutations were induced in the FoxO protein at site of the amino acids indicated in bold.

For clade 1.1, the virus that had the R430W mutation showed reduced inhibition by oseltamivir, zanamivir, and laninamivir; in clade 2.3.2.1, the virus that had the H275Y mutation showed highly reduced inhibition by oseltamivir and peramivir.

Transgenic mice with a β4-integrin signaling domain mutation showed reduced prostate tumor formation and progression, thus supporting our data that ITGB4 is involved in tumor cell migration and metastasis [ 41].

All spc110 mutant alleles with SPM or CM1 inactivating mutations showed reduced growth in the mad2Δ background compared to MAD2 SAC proficient cells.

Orc6-W228A/K229A is not able to rescue an Orc6 deletion in Drosophila to support viability in vivo, and cells bearing the two mutations showed reduced BrdU incorporation in brain neuroblasts, suggesting defects in DNA synthesis (Balasov et al., 2009).

Since succinimide is an established coupling reagent for amide bond synthesis,[ 12] we probed the role of Asp147 which is strictly conserved in all known legumains but is often a serine in caspases.[ 13] While the legumain D147S and D147G point mutations showed (reduced) proteolytic activity and hence correct folding, they totally lacked any ligase activity.

Transgenic knock-in mice carrying the S80A mutation show reduced MeCP2 binding to target genes and consequently aberrant gene expression (Tao et al., 2009).

The probe containing −55AG and −54AC mutations (pJM8) showed reduced synergistic binding, relative to the wild-type probe.