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Mice possessing the conditional Dlk1 mutation showed higher proportions of self-renewing cells at the expense of fewer proliferating cells (Fig. 4).

P450 BM3 variants containing V87I and V87F mutation showed high selectivity for benzylic and aromatic hydroxylation of 1 respectively.

SeFabI[G93V] mutation showed high level luteolin resistance, which was consistent with the studies in E. coli by triclosan.

All of the cases with the polypyrimidine-tract mutation showed high-frequency microsatellite instability.

iPSC-derived CMs created from a patient with RyR2F2483I heterozygous mutation showed high amplitude and long duration of spontaneous Ca2+ release at basal state.

Overall, we observed that early mutations showed higher allele frequencies when compared to the intermediate (P = 0.026, t-test) and late (P = 0.0015, t-test) mutations.

As a result, cells bearing R248W and R282W mutations showed higher viability than the control group after incubation with etoposide for 48 h.

In contrast, fibroblasts with the cancer-associated promoter mutations showed high levels of TERT expression.

The remaining nine genes in the QTL region, each with a non-synonymous mutation, (Table  8 ) showed higher expression in G. max than in G. soja, except for Glyma06g46210.

Clinical isolates expressing the H275Y mutation show high-level oseltamivir resistance (mean in vitro 50% inhibitory concentration [IC50] ± standard deviation [SD], 679.5 ± 44.5 nM) and intermediate peramivir resistance (mean IC50 ± SD, 36.5 ± 7.8 nM) without a change in zanamivir susceptibility [ 32]; the clinical significance of this finding, however, is not clear.

In postmortem sections from two PD cases with PARK2 gene mutations, NM+ neurons showed higher levels of RTP801 expression.