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Hence, the C2576T mutation should occur with a theoretical frequency ranging from 0 85% (average 43%) depending on the template preference for the DNA repair reaction (Figure 1C).
Therefore FAK induction by APC mutation should occur earlier than PYK2 elevation.
FAK induction, although further enhanced in tumors, however, is triggered by APC mutation the initiating event for tumorigenesis in the APC-mutant mice, through activated Wnt pathway target c-Myc (Ashton et al., 2010); therefore FAK induction by APC mutation should occur earlier than PYK2 elevation.
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Theory cannot reliably predict what kind of mutations should occur; it only predicts the fate of mutations with given effects.
From a population genetics standpoint, a large proportion of mutations should occur in the external branches when the infected hosts have rapidly increased.
This means that if there is no outside pressure, mutations should occur in random rather than in a certain direction under the condition of pressure.
> In the absence of selection, mutations should occur at random across the genome and so not be biased by, for example, differences between selection on coding versus non-coding regions or non-synonymous versus synonymous codon positions.
Generally, it is suggested that mutation process should occur with a low probability.
Pledges to vaccinate hundreds of millions of birds have not been met.The UN's Food and Agriculture Organisation is starting to establish local disease-control centres to cope with the effects of a virulent mutation, should one occur, but reckons that only one-third of the country will be covered by year's end.
Therefore, the causative mutation for the pro23 phenotype should occur with 100% penetrance, i.e. present in all reads covering the corresponding position(s), in the pro23/fus sample only, but not in the pro44, fus, or wild-type samples.
If mutation rates are uniform across the yeast genome, each of the mutations that create ochre suppressors should occur with equal probability.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com