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Thus, if an ubiquitin binding effector is required for Ub-EEA1 to induce enlarged endosomes, the mutation should abolish the phenotype.
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To test whether this predicted structure plays a role, we introduced ten mutations that should abolish a hairpin loop but preserve the amino acid sequence.
For example, while inactivating mutations in Tβ R- II should abolish all TGF-β responses, inhibition of SMAD signaling by various mechanisms will block SMAD-dependent responses, such as growth inhibition, to varying extents and will allow potential SMAD-independent TGF-β effects to remain intact.
"Overall, the UK government should abolish 20 current taxes.
He should abolish the death penalty in his kingdom.
12.21pm BST Q: You should abolish zero-hours contracts completely.
Fifth, we should abolish the death tax.
This should abolish KLF4 and TFAP2A binding.
The criteria for selection were that the mutations should create or abolish one or more ESE sites according to the predictions of at least one algorithm.
However, unlike the NL3 R451C mutation, the NL4 R87W mutation abolished NL4-induced synapse formation [ 13].
Thus, the A41D mutation will abolish AcrR's repressive activity.
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CEO of Professional Science Editing for Scientists @ prosciediting.com