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Such alleles may arise from somatic mutation, sharing of cells between dizygotic twins, fetal-maternal cell transfer, and a number of other mechanisms [ 10- 12].
We next performed a more sensitive breakpoint genotyping step in order to exclude germline SV breakpoints that may have been misclassified as somatic mutations due to inadequate coverage in the diploid (D) sample, and to obtain more accurate patterns of mutation sharing among the tumor subpopulations.
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On the basis of 19 Y chromosome biallelic loci, Su et al. (1999) estimate an age of 18,000 to 60,000 years for the O-M122T → C mutation shared by "Asian-specific" haplotypes H6 H8.
But a new study appearing online today in Science reveals a mutation shared by housecats and cheetahs, which may explain how the cat got its stripes or in this case, its blotches.
The first lesion exhibited 2 mutations where as the second one exhibited 3 with one identical mutation shared with M1 (A10995C, Fig. 2A B, matched color).
The lens cataract and myopathic muscle in mutant mice and humans with the αB-crystallin R120G mutation shared common pathological features and molecular mechanisms.
We found no mutation shared between tarsier and either New World monkeys or catarrhine primates; again, it is not possible to determine whether GC-D function was lost before these species diverged, or lost independently in all three lineages.
We did not observe any inactivating mutation shared between New World monkeys and catarrhine primates, and thus cannot determine whether GC-D was already non-functional in the simian ancestor, or whether function was lost independently in the two lineages.
The R273H mutation shared serine hydrolase pathway with R282W, but R175H did not show significant similarity with other mutations.
Thus, the probability that a given nucleotide position has an erroneous mutation shared by more than k isolates is.
Therefore, taken together, we defined a "nodal mutation" as a mutation shared by at least five sequences comprising at least 85% of the sequences within a given branch.
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