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Although some such variants may be pathogenic, this effect is allowed for in the model by the mutation sensitivity parameter (i.e., the incomplete sensitivity is partly due to pathogenic mutations classified as VUSs).
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Mutation sensitivity differed by up to 10-fold between promoters.
Furthermore, mutation sensitivity was reduced upon introduction of a binding site for Reb1, a factor that blocks nucleosome formation, suggesting that nucleosome organization directly regulates mutation sensitivity.
Fixed sensitivity parameter values and inverted the relationship between touch sensitivity preference and synclient parameter value.
e Sensitivity parameter ν = 0.05.
The sensitivity parameters for BRCA1 and BRCA2 mutation screening were set as 70%and80%0% respectively.
To allow for the fact that not all mutations could be detected by the screening methods used, we allowed in our analysis for a sensitivity of mutation testing parameter, giving the probability of detecting a mutation if one exists.
Various parameter estimates of the more sensitivity model parameters spanned in a small neighborhood of the accepted optimal parameter estimates.
A one-way sensitivity analysis found that the most two sensitive parameters were the HR of PFS for the Gefitinib strategy in patients with EGFR mutations and the utility of progression free survival regardless of the use of the GPAP.
sensitivity based parameter estimation technique.
In univariate sensitivity analyses, parameters were varied by ±50%.
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CEO of Professional Science Editing for Scientists @ prosciediting.com