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While cancer resembles RH clones in some respects, cancer cells differ in several important aspects such as mutation, selection, heterogeneity of fragment length and differences in genome coverage.
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This model for biofilm growth is analogous to mutation selection that occurs during neoplastic progression and tumor development, and may help to explain why structural and genetic heterogeneity are characteristic features of bacterial biofilm populations.
Proteins evolve by iterative cycles of mutation, selection and amplification.
Step 1: Mutation selection.
At least five selection mechanisms are hypothesized to maintain genetic variation in nature: mutation-selection balance, heterosis, antagonistic pleiotropy, negative frequency-dependent selection (advantage of rare genotype) and environmental heterogeneity [2], [7].
Penke, Denissen and Miller argue that a mutation-selection standoff is the explanation for why we differ in intelligence.
This might include a large fraction of medically detrimental mutations that are not eliminated by purifying selection, possibly due to positive selection or mutation-selection balance [33].
- Mutation-selection balance was achieved.
Prognostic factors examined included baseline TLG, RAS mutation status, FDG heterogeneity and dose heterogeneity.
Author's response: Because we use the rate of only parallel synonymous evolution as a proxy for mutation rate, heterogeneity of the rate of evolution across synonymous sites, due to heterogeneous mutation and/or selection, should not be a problem.
These processes (mechanisms) include (but are not limited to) mutation, natural selection, random drift, sexual selection, and speciation.
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