Sentence examples for mutation screening method from inspiring English sources

However, once primers and conditions are chosen, TGGE/DGGE is a robust and easy to perform mutation screening method particularly well suited for the detection of known and unknown mutations in large genes, where high sensitivity is required and when large numbers of samples are to be tested.

The analysis of the data from most targeted DNA analysis methods is straightforward in that it is similar to that required for any other gene mutation screening method.

The SMARCB1 mutation screening method we describe is rapid, sensitive and inexpensive and will be useful for both diagnostic molecular pathology and molecular genetics laboratories.

SSCP and RFLP, the most widely used techniques for mutation screening method in genetic diagnostic laboratories, were not able to detect every mutation, so development of new methods was needed.

The cost calculations presented here show that a modest total financial saving of around £2500 per year may be obtained by choosing MLPA as the initial mutation screening method for all hereditary cancer referrals (for a region with a population of 3 million people), as well as the additional advantage of quicker reporting times for positive individuals.

Comprehensive mutational analysis of the entire mitochondrial genome achieved by direct sequencing of approximately 80% of the mitochondrial genome [ 3, 6] or by the use of TTGE mutation screening method with overlapping primers covering the entire genome was limited to only a few studies [ 7, 8, 11- 13].

The sensitivity of the technique in our conditions (93.8%) was comparable to other mutation screening methods [9].

Additional file 1: p53 mutation screening methods.

Accurate identification of mutations is a crucial aspect of all mutation screening methods.

Mutation screening for BRCA1 and BRCA2 is not 100% sensitive and can vary depending on the mutation screening methods used.

In addition, the sensitivity of HRMA compared to that of other mutation screening methods was not assessed in either study.