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Among these 17 mutants, five had a mutation score equal or greater than 10, indicating a possible homozygous mutation.
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For this analysis only mutation pairs that have a covariance score equal to or greater than 0.5 (cut-off value taken from Aurora et al. [ 31]) were considered for further analysis.
More precisely, for every gene, the gain/mutation score is equal to the product of the mutation score and the sum of the recurrence and focality gain scores for that gene.
The main outcome of the mutation analysis is the mutation score, which indicates the effectiveness of a test suite.
It is possible to realize that the column "Mutation Score" contains the mean of the mutation scores obtained by each test set (RP_1), (RR_1), (RP_2) and (RR_2), respectively.
Clearly the mutation score obtained by the combined test sets is always greater than the score obtained by individual sets.
The total score is the addition of scores over the 25 sites with a score equal to or greater than 20 representing high risk.
Considering the mean of 30 (RP_1) sets, a mutation score of 90.7 % was obtained.
4) totally recovered: a pain score less or equal to 1 and a disability score equal to 0 (CPQ).
To estimate the false negative error rate, the total number of ancestral mutations that should have been scored (equal to the product of the number of mutations in the ancestor and the number of MA lines) was compared to the number actually scored, and the probability of missing a mutation was calculated.
Of note, entropy itself for deleterious mutations is closer to 0 than for benign mutations and has high F-score equal to 0.66.
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CEO of Professional Science Editing for Scientists @ prosciediting.com