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During mutation, samples that undergo mutation are mutually independent.
The resistance mutation samples were collected in the US and Canada during 1998 2005, and included a portion of US samples from a previously reported surveillance study [19].
Of the 213 individuals who could be inferred to have a p53 mutation, samples were available for 132 individuals, but MDM4 genotypes were missing for two of these individuals.
All other full mutation samples have, as expected, reduced expression of FMR1 (Fig. 3c).
In this study, however, we found a borderline trend for lower levels of Ki67 in mutation samples overall.
We detected a twofold change in differential gene expression between the normal and GCD2-homozygous (Arg124His mutation) samples.
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Of course, as Pack himself is quick to point out, even combined with Fu's data the mutation sample remains miniscule.
Each small block square indicates one unique mutation sample for LATS1/2 from human cancer.
The other p53 mutation sample had a c-CBL LOH with concurrent MET N375S mutation.
A normal control DNA sample (without the K-Ras codon 12 mutation) and a known mutation sample were included in all experiments.
A wild-type control DNA sample (without K-Ras and B-Raf mutations) and a known mutation sample were also included in the experiment.
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