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Although a subset of patients have well-characterized genetic mutation(s), in the majority of cases, the etiology is unknown.
It is now possible to simultaneously map the effect of mutation(s) in each and every gene in the genome onto almost any screenable or selectable phenotype in less than a week.
Based on the results in Table 7, unidentified mutation(s) in CAG18439 may cause expression of pheromone activity.
Therefore, the changes in CQ and QN resistance phenotypes in the mutants could be largely attributed to the key mutation(s) in PfCRT.
To determine whether a mutation(s) in the Agouti locus is associated with melanism, we genotyped the 49 offspring of an A+/a−×A+/a− cross.
These results suggest that unidentified mutation(s) in the CAG18439 chromosome other than Tn10 and lacI cause the high transformation frequency in CAG18439.
Additional studies would contribute to identifying the mutation(s) in genes involved in the midgut response to pathogens and to clarify the role of REPAT and arylphorin in response to pathogens.
Mutation(s) in proteins are a natural byproduct of evolution but can also cause serious diseases.
Mutation(s) in housekeeping proteins often lead to serious ailments in humans [ 1].
For genetic testing, there are several advantages to knowing the founder mutation(s) in a population.
(1) A drug binds to a protein that directly involves the mutation(s) in the pocket.
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