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This is in line with a recent observation that the mvp mutation reveals important changes in global gene expression [ 29].
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First, this mutation may reveal important mechanistic information about the molecular triggers for FTD and ALS, thus allowing the identification of novel drug targets.
But a closer look reveals important nuances.
This index also reveals important geographic trends.
It has been shown that ferredoxin and FNR have very tight binding with Kd in the range of 10 7 10 8 M. As discussed previously, several surface amino acid residues are conserved in ferredoxins, and mutation of these amino acids revealed important factors in interaction between these redox partners.
Bermingham, J. R. Jr et al. The claw paw mutation reveals a role for Lgi4 in peripheral nerve development.
An analysis of culprit mutations in LQTS types 1 3 has revealed important features that provide a framework to differentiate between pathogenic and benign variants.
The identification of naturally occurring missense mutations in SF1 is also helping to reveal important functional domains for nuclear receptor action.
Mice with mutations in the β-catenin signaling pathway have also revealed important information about colon cancer pathogenesis, along with models for hereditary nonpolyposis colon cancer and inflammatory bowel diseases associated with colon cancer.
Characterization of breast tumors for the ESR1 A908G point mutation, shown by Fuqua and colleagues [ 9] to be hypersensitive to estrogen, may reveal important etiologic clues.
Their results reveal important asymmetries.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com