Sentence examples for mutation results obtained from inspiring English sources

Finally, we employed massively parallel array-based pyrosequencing-by-synthesis [20] to validate mutation results obtained by conventional dideoxy and pyrosequencing.

The stem cell gene expression and mutation results obtained in this study support the model that through the acquisition of genetic mutations, breast stem cells obtain malignant capacities, while retaining stem cell-associated functions.

100% concordance was achieved in the DNA mutation analysis results obtained between the two reference laboratories.

We report mutation analysis results obtained with the tetranucleotide microsatellite marker D7S1482, which is a hypermutable marker in both germline and somatic cells (Temam et al, 2003; Slebos et al, 2004a).

This evidence was further corroborated for the VARS2 mutation by concordant results obtained in a recombinant yeast model.

At earlier time points, no significant differences were observed with the RGD mutations, similar to the results obtained following complete deletion of the protein (Fig. 3D).

These stimulatory effects of BMPRII and ACTRIIB mutation were consistent with the results obtained from transient gene expression experiments in the absence of BMP7 suggesting that wild type BMPRII as well as ACTRIIB receptors were involved in mediating a negative regulation of telomerase activity.

This predicted pathogenicity was based on the type of mutation (frameshift) or on the results obtained from in vitro functional analysis.

Results obtained from mutation analysis of the two potential NLS motifs from two related tomato Hsfs (HsfA1 and HsfA2) indicated that only one of the two motifs adjacent to the HR-A/B region, and not the conserved C-terminal part of the DBD domain is functional as an Hsf protein nuclear localization signal [ 16, 17, 22].

The lack of consensus concerning the effects of PSEN FAD mutations on γ-secretase-dependent and -independent functions and the heterogeneity of results obtained for individual mutations clearly demonstrate that a better understanding of FAD PSEN mutations will require improved cellular models.

In this model we observed a dependency of TDP-43-mediated neurotoxicity on RNA-binding activity, but not mislocalization, truncation, or missense mutations, therefore accurately mirroring the results obtained by same-level TDP-43 expression in Drosophila.