Sentence examples for mutation restoring the from inspiring English sources

AO therapy could be used in specific CF cases to alter splicing to skip an exon containing a nonsense or frameshift mutation, restoring the reading frame, assuming the resultant isoform retained better function than the mutated protein.

The introduced BZcon1 gene fully complemented the BZcon1 null mutation, restoring the capability for sporulation.

One G418-resistant complementary transformant, C113-2, fully complemented the CAN13 null mutation, restoring the capability for sporulation (Table 1 and Figure 4B).

Second, the presence of multiple copies of the lacZ- allele makes more likely the chance occurrence of a mutation restoring the wild type (LacZ+) activity, and thus optimal growth on lactose.

An interesting scenario, albeit still hypothetical in the light of this data, is that the switch to commercial potato could have counter-selected the glycine form of AChE2, whereas the later usage of OP insecticides could have selected for the S291G mutation restoring the frequency of the ancestral genotype.

Remarkably, a one-nucleotide mutation within the 5′UAR was correspondingly co-selected; the 5′UAR mutation restored the base pairing with the 3′UAR mutation.

Back mutation restored the colonization ability.

Importantly the inhibition of the RAS pathway in cells harboring BRAFV600E mutation restores the LKB1-AMPKα pathway by permitting the re-association of the LKB1-AMPKα complexes.

All plants tested were more susceptible than the resistant Kas-1 ecotype and complementation of the atl9 mutation restored the wild-type defense phenotype (data not shown).

The N146A mutation restored the interaction with the complex, while the W155A mutation did not (Fig 3C), indicating that the protruding tryptophan is an essential residue for interaction with the complex.

Notably, the I539T mutation restored the wild-type NBD1 pattern in ΔF508: both protease resistant bands of ∼25 and 27 kDa that had been lost in ΔF508 NBD1 returned upon mutation of I539 to Threonine (Figure 4A, ◂).